Wednesday, October 17, 2007
Halotestin ( HALOTESTEX )
Halotestin ( HALOTESTEX ) Buy Halotestin Haltestin is generally considered one of the two most toxic steroids available (the other is methyltestosterone). It is an oral c17-alpha-alkylated compound that provideds nice strength gains without much weight gain at all. It has low anabolic qualities dispite it's huge anabolic rating, meaning that the drug alone failed to provide significant muscle mass gains. Power lifters seeking improved personal records and strength while maintaining a certain body weight favor this drug. Bodybuilders used it successfuly to improve muscle hardness as well as agression in the gym during the last 4-6 weeks of calorie depletion before competition. The increased agressiveness is very useful in the gym, and of course, must be controlled outside of it. Halotestin is one of the drugs infamous for promoting "roid-rage." However, it does not aromatize and water retention (and resulting high blood pressure) almost never results from its use. Most users feel that it must be stacked with an injectable drug such as TESTOSTERONE, EQUIPOISE or DECA, to acheive any sort of appreciable lean muscle mass gains. Normally males take 20-40 mg daily divided into 2-3 even dosages for 3-6 weeks, or simply take their dose an hour before training. Pictured above are British Dragon halotestin 10mg tablets Use of Halotestin is quite hard on the liver, and is often limited in use to 4-6 weeks at most. Reported Characteristics Pharmaceutical Name: Fluoxymesterone Chemical Name:17b-hydroxy-11b,17-b-dihydroxy-17a-methyl-4-androstene-3-one Cutting/Bulking:Cutting Anabolic Rating: 1900 (!) Active-Life: 6-8 hours Drug Class: High androgenic/anabolic steroid (Oral) Average Dosage: Men 20-40-mg daily Women: none Acne: Common Water Retention: None High Blood Pressure: Rare Liver Toxic: Very Aromatization: No DHT Conversion: No Decreases HPTA function: Possible Average Price:.25cents per 5-10mg tab Trade Names HALOTESTEX 10MG (British Dragon) ANDROID –F 10-MG TABS HALOTESTIN 2MG TABS HALOTESTIN 5MG TABS HALTESTIN 10MG TABS HYSTERONE TABS 20MG TABS ORA-TESTRYL 5MG TABS STENOX 2.5MG TABS
Monday, October 15, 2007
Dianabol ( Dbol ) - Methandrostenolone
Dianabol ( Dbol ) - Methandrostenolone
This was more or less the second Anabolic Steroid ever produced. The first, as we all know was Testosterone, which was produced in the early 1900´s and experimented with by Nazi´s in WW2, in an attempt to produce a better soldier.
Russian Dianabol and Team Sports HistoryR ussian athletes in the 1953 World Championships as well as the Olympic games then used testosterone with great success. After that, John Zeigler, who was a doctor working with the US Weightlifting Team, began a cooperative project with Ciba to develop an equalizer for US atheletes. Flash forward to 1956 and enter Dianabol ; the original trade name for Ciba´s Methandrostenolone... but called "Dbol" by athletes. The original package insert said that 10mgs/day was enough to provide full androgen replacement for a man and Dr.Zeigler recommended that athletes take 5-10mgs/day. Incidentally, this is also the dose that Bodybuilders were reputed to take from then until roughly the 1970´s. Yeah, this was allegedly Arnold´s dose, Zane´s dose, etc... simply stacked with some testosterone. (For any trivia buffs out there, Dan Duchaine´s mail order steroid business operated under the name "The John Zeigler Fan Club").
Dianabol Steroid Use
Enough with the history lesson, lets get into what this stuff is, and what it does. Well, first off, it´s usually found in pill form, though it can be found as an injectable also (Under the Trade name: Reforvit-B, which is 25mgs of methandrostenolone mixed with B-vitamins). It is a 17aa steroid, which means it has been altered at the 17th Carbon position, to survive its´ first pass through your liver, and make it into your blood stream. It´ll raise your blood pressure (4) and is also hepatoxic (Liver-Toxic), so be careful with it. Although I have known people to take up to 100mgs/day of this stuff and not suffer any ill-effects, and one study looked at that exact dose, and the people involved didn´t suffer any intolerable side effects ( 7). Lets examine this particular study a bit further, though:
In this study, done in the early 80´s, a very high dose of Dbol (100mgs/day for 6 weeks) decreased plasma testosterone to about 40% of it´s normal value, plasma GH went up about a third, LH dropped to about 80% of it´s original value, and FSH went down about a third also (these are all approximate numbers, for the sake of brevity, but you get the idea). Body fat did not go up significantly and Fat Free Mass went up anywhere between 2-7kgs (3.3kgs average gain). The researchers concluded that Dbol increases Fat Free Mass as well as increasing strength and performance. I can only agree, having found this to be the case for me when I did my first cycle (which was 6 weeks of dbol alone at 25mgs/day), I gained roughly 25lbs and kept nearly ½ of it. Since then, Dbol has always had a special place in my heart.
Dianabol Side EffectsAs with many other 17aa steroids, Dianabol is also a very weak binder to the Androgen Receptor, so most of it´s effects are thought to be non-receptor mediated, and are attributable to other mechanisms (i.e. protein synthesis as indicated by the production of muscle tissue with very high levels of nitrogen, etc... which was indicated in the 100mg/day study). This also means it only has a modest aromatase activity (2).
How strong is Dbol? Well...on a mg for mg basis, most people agree that it´s stronger than A50...but the reason most people don´t get the same gains off of Dbol is that almost nobody takes equivalent doses (I mean...I´ve heard of people taking 150mgs of A50, but not Dbol, even though the dbol would probably provide more solid gains and be less toxic, I suspect).
So how do we incorporate this stuff into our AAS regimen? Clearly, the inclusion of Dbol at any point in a cycle would contribute to gains, however, I´d speculate that Dbol is most regularly used for 2 reasons:
At the start of a cycle to "Kick Start" gains As a "Bridge" between cycles, to maintain gains Lets examine these two uses.
Dianabol Cycle
In order to kick start a dianabol cycle, usually what you do is incorporate a fast acting oral like dianabol (or anadrol) and combine it with long acting injectables (such as Deca or Eq with some Testosterone). The reasoning here is that the oral (Dbol in this case) will give almost immediate results, while the injectable takes time to produce results. The end result is that you start seeing results within the first week of your cycle and continue up until the end with the injectables. This entails taking anywhere from 25-50mgs of dbol (although as little as 20mgs or as much as 100mgs have been reported) for 3-6 weeks at the start of a cycle (average time for a "Kick Start" is 4 weeks, though), and then ceasing their use as the injectables start to produce results.
In order to successfully bridge between cycles (and this means using a low dose of AAS, in this case dbol), you need to recover your natural hormonal levels to pre-cycle levels or to within acceptable parameters, and then you start your next cycle. The idea here is that you won´t lose any gains, but rather a low dose of an AAS will help you maintain them. Typically, you´d use around 10mgs/day of dbol and combine it with an aggressive Post-Cycle Therapy (PCT) course of Nolvadex (and/or Clomid) and HCG. This would give you full androgen replacement from the Dbol and a shot at recovering your natural hormonal levels via the other stuff you are taking. Remember, the 100mg/day dose of dbol in the study we looked at earlier did not suppress Test, LH, or FSH to a degree that would make recovery impossible and certainly not with 1/10th that dose in conjunction with an aggressive PCT.
All in all, this is a very good drug, and a potent tool for quick gains or retaining gains...when used properly and safely.
This was more or less the second Anabolic Steroid ever produced. The first, as we all know was Testosterone, which was produced in the early 1900´s and experimented with by Nazi´s in WW2, in an attempt to produce a better soldier.
Russian Dianabol and Team Sports HistoryR ussian athletes in the 1953 World Championships as well as the Olympic games then used testosterone with great success. After that, John Zeigler, who was a doctor working with the US Weightlifting Team, began a cooperative project with Ciba to develop an equalizer for US atheletes. Flash forward to 1956 and enter Dianabol ; the original trade name for Ciba´s Methandrostenolone... but called "Dbol" by athletes. The original package insert said that 10mgs/day was enough to provide full androgen replacement for a man and Dr.Zeigler recommended that athletes take 5-10mgs/day. Incidentally, this is also the dose that Bodybuilders were reputed to take from then until roughly the 1970´s. Yeah, this was allegedly Arnold´s dose, Zane´s dose, etc... simply stacked with some testosterone. (For any trivia buffs out there, Dan Duchaine´s mail order steroid business operated under the name "The John Zeigler Fan Club").
Dianabol Steroid Use
Enough with the history lesson, lets get into what this stuff is, and what it does. Well, first off, it´s usually found in pill form, though it can be found as an injectable also (Under the Trade name: Reforvit-B, which is 25mgs of methandrostenolone mixed with B-vitamins). It is a 17aa steroid, which means it has been altered at the 17th Carbon position, to survive its´ first pass through your liver, and make it into your blood stream. It´ll raise your blood pressure (4) and is also hepatoxic (Liver-Toxic), so be careful with it. Although I have known people to take up to 100mgs/day of this stuff and not suffer any ill-effects, and one study looked at that exact dose, and the people involved didn´t suffer any intolerable side effects ( 7). Lets examine this particular study a bit further, though:
In this study, done in the early 80´s, a very high dose of Dbol (100mgs/day for 6 weeks) decreased plasma testosterone to about 40% of it´s normal value, plasma GH went up about a third, LH dropped to about 80% of it´s original value, and FSH went down about a third also (these are all approximate numbers, for the sake of brevity, but you get the idea). Body fat did not go up significantly and Fat Free Mass went up anywhere between 2-7kgs (3.3kgs average gain). The researchers concluded that Dbol increases Fat Free Mass as well as increasing strength and performance. I can only agree, having found this to be the case for me when I did my first cycle (which was 6 weeks of dbol alone at 25mgs/day), I gained roughly 25lbs and kept nearly ½ of it. Since then, Dbol has always had a special place in my heart.
Dianabol Side EffectsAs with many other 17aa steroids, Dianabol is also a very weak binder to the Androgen Receptor, so most of it´s effects are thought to be non-receptor mediated, and are attributable to other mechanisms (i.e. protein synthesis as indicated by the production of muscle tissue with very high levels of nitrogen, etc... which was indicated in the 100mg/day study). This also means it only has a modest aromatase activity (2).
How strong is Dbol? Well...on a mg for mg basis, most people agree that it´s stronger than A50...but the reason most people don´t get the same gains off of Dbol is that almost nobody takes equivalent doses (I mean...I´ve heard of people taking 150mgs of A50, but not Dbol, even though the dbol would probably provide more solid gains and be less toxic, I suspect).
So how do we incorporate this stuff into our AAS regimen? Clearly, the inclusion of Dbol at any point in a cycle would contribute to gains, however, I´d speculate that Dbol is most regularly used for 2 reasons:
At the start of a cycle to "Kick Start" gains As a "Bridge" between cycles, to maintain gains Lets examine these two uses.
Dianabol Cycle
In order to kick start a dianabol cycle, usually what you do is incorporate a fast acting oral like dianabol (or anadrol) and combine it with long acting injectables (such as Deca or Eq with some Testosterone). The reasoning here is that the oral (Dbol in this case) will give almost immediate results, while the injectable takes time to produce results. The end result is that you start seeing results within the first week of your cycle and continue up until the end with the injectables. This entails taking anywhere from 25-50mgs of dbol (although as little as 20mgs or as much as 100mgs have been reported) for 3-6 weeks at the start of a cycle (average time for a "Kick Start" is 4 weeks, though), and then ceasing their use as the injectables start to produce results.
In order to successfully bridge between cycles (and this means using a low dose of AAS, in this case dbol), you need to recover your natural hormonal levels to pre-cycle levels or to within acceptable parameters, and then you start your next cycle. The idea here is that you won´t lose any gains, but rather a low dose of an AAS will help you maintain them. Typically, you´d use around 10mgs/day of dbol and combine it with an aggressive Post-Cycle Therapy (PCT) course of Nolvadex (and/or Clomid) and HCG. This would give you full androgen replacement from the Dbol and a shot at recovering your natural hormonal levels via the other stuff you are taking. Remember, the 100mg/day dose of dbol in the study we looked at earlier did not suppress Test, LH, or FSH to a degree that would make recovery impossible and certainly not with 1/10th that dose in conjunction with an aggressive PCT.
All in all, this is a very good drug, and a potent tool for quick gains or retaining gains...when used properly and safely.
Wednesday, October 10, 2007
Clomiphene Citrate (Clomid)
Clomid is the anti-estrogen of choice for improving recovery of natural testosterone production after a cycle, improving testosterone production of endurance athletes, and is also effective in reducing risk of gynecomastia during a cycle employing aromatizable steroids.
While it has been claimed that Clomid "stimulates" production of LH and therefore of testosterone, in fact Clomid’s activity is achieved not by stimulation of the hypothalamus and pituitary, but by blocking their inhibition by estrogen.
Clomid is a mixed estrogen agonist/antagonist (activator/blocker) which, when bound to the estrogen receptor, puts it in a somewhat different conformation (shape) than does estradiol. The estrogen receptor requires binding of an estrogen or drug at its binding site and also the binding of any of several cofactors at different sites. Without the binding of the cofactor, the estrogen receptor is inactive. Different tissues use different cofactors. Some of these cofactors are able to bind to the estrogen receptor/Clomid complex, but others are blocked due to the change in shape. The result is that in some tissues Clomid acts as an antagonist -- the cofactor used in that tissue cannot bind and so the receptor remains inactive -- and in others Clomid acts as an agonist (activator), because the cofactors used in that tissue are able to bind.
Clomid is an effective antagonist in the hypothalamus and in breast tissue. It is an effective agonist in bone tissue, and for improving blood cholesterol.
Clomid also has the property of reducing the adverse effect of exercise-induced damage of muscle tissue. This is very significant for endurance athletes but is not very significant, if at all significant, with reasonable weight training. Clomid does not perceptibly affect gains of the weight trainer either favorably or adversely in my experience.
The drug seems to have estrogenic effects on mood, which can be beneficial (improving relationships with women by improving empathy) or can yield depression or PMS-like symptoms, but for most users there is no significant effect either way.
The claim that duration of intake should not exceed 10-14 days is incorrect. Clinical studies with male patients have been for periods of a year or longer. This error probably originates from the fact that, for use in women, due to the menstrual cycle there would obviously be no point in trying to stimulate ovulation all four weeks of the month. Thus, use in women is limited to 10-14 days. That limitation is not because of toxicity.
Clomid is in fact useful throughout a cycle if aromatizable drugs are being used. I do think however that to be conservative, one should use it no more than 2/3 of the time throughout the year or a little less.
Trivial name Clomiphene Systematic name Ethanamine, 2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethyl- CAS number 911-45-5 or 50-41-9 (citrate (1:1)) ATC code G03GB02 Merck Index Number 2410 Chemical formula C26H28ClNO or C32H36ClNO8 (citrate) Molecular weight 405.9663 g/mol (without citrate)598.0913 g/mol (with citrate) Bioavailability High (>90%) Metabolism Hepatic (with enterohepatic circulation) Elimination half-life 5-7 days Excretion Mainly renal, some biliary Pregnancy category X Legal status Prescription only (US) Controlled substance No Routes of administration Oral
Tuesday, October 9, 2007
Sachets - Future Of Injectables?
Sachets - Future Of Injectables? The Evolution Of Injectable Steroid. 5ml's of injectable steroids in a slick new packet I can remember over half a decade ago, when paper anabolics first burst onto the scene. They originated in Thailand, and were in huge demand- as they still are. This raised a question in everyone The Evolution Of Injectable Steroid. 5ml's of injectable steroids in a slick new packet Now, nearly half a decade later, this product has arrived on the underground scene. Before I get into that, I’m going to tell you what I won’t do. I won’t be helping customs figure out how to stop this product, or helping anyone obtain it. Everybody in the underground scene was done a great disservice a few years back when paper anabolics and a description of them appeared in a very well known steroid book, as well a major bodybuilding magazine, finally having pictures of them appearing in an obnoxious newsletter that somehow everyone in the world ended up on the mailing list for. That’s not going to happen here, I’ll assure you. Thankfully, paper anabolics are still a great way to safely receive oral anabolics; and finally there’s a way to safely receive injectables too! The main problem with figuring out a way to safely transport injectable anabolics is how to keep them sterile, and yet still transport them in a container that will get through customs. A few manufacturers in the past (kind of) solved this issue by shipping in bottles of dubious quality and sterility, labeling them as something else. And you know what? It worked- kind of. The problem was that the bottles weren’t really sterile and once you had them, you had to transfer the oil into a sterile multi use vial, and filter it, then perhaps bake it- in order to insure that it was sterile. It was a pain in the ass, honestly, and that manufacturer eventually went out of business. So until recently, that was the end of the story. Now, there’s something new on the underground market, which is good news to everyone who wants their injectable oils guaranteed to arrive safely. I first heard about this product about half a year ago, and now that I have the manufacturer’s permission, I’m going to tell you about it. The product is known by some people (for obvious reasons) as “Stealth Injectables” and is produced by the Natural-Oils company. Before I go any further, let me state that the products I’m telling you about are clean, sterile, and accurately dosed. And now I’m going to tell you how this has been accomplished… When you and I go to the store to buy something that is presumably sterile, it often comes in a multi-use container. Think about antiseptic cream (Bacitracin, Neosporin, etc…). It’s sterile, right? And it comes in a little tube, containing the sterile cream. However, when you go to the hospital (or a piercing studio, tattoo parlor, etc…any Hygienic facility), the antiseptic cream comes in single serving containers; to avoid contamination…it comes in single use sterile sachets…that’s actually more safe than the multi use containers, because there’s no risk of opening the container and then resealing it. Amps use the same technology- sealed single use containers of oil. Well, if you combine those two ideas…you’ll have an idea of what this underground manufacturer has done. What we have here is a sachet that contains 5mls of sterile anabolic steroid oil, and can be mailed anywhere without detection: SO all you have to do is stick a needle into the sachet, and pull out 5mls of oil and either use it, or transfer it to another sterile multi-use container. You can even pull out 1ml into 5 separate syringes, then cap and cover them for later use…whatever’s most convenient for your cycle… So now, you can get sterile, accurately dosed sachets of anabolic oils mailed to you safely… of Deca, EQ (both at 200mgs/ml), Sustanon, Supertest (a high dosed testosterone blend), Testosterone Propionate (100mg/ml), Enanthate or Cypionate (250mgs/ml), as well as Masteron or Trenbolone Acetate (both dosed at 100mgs). So it took a long time, but the injectable answer to paper anabolics is finally here. The quality of these products is high, as is their effectiveness- and the risk of customs seizing them is low as is their price. If you can get your hands on them, I highly recommend you try them out!
Saturday, October 6, 2007
Sildenafil Citrate (Viagra)
Viagra works by increasing the effects of nitric oxide (NO), a substance that serves many key functions in biological processes throughout the body. One of the most well known and important functions of NO is the dilation of blood vessels. This allows greater blood flow to the muscles, which of course can be valuable to an athlete during competition. What is more interesting to me is the role of NO on muscles during resistance training. JE Anderson found that NO appears to be a vital signal in the activation of muscle satellite cells in response to damage. Satellite cell activation is the key first step in the repair and hypertrophy of muscle cells after heavy training. Viagra may therefore enhance the hypertrophy response to exercise, working at the most basic and primary level of the process. In addition to this, there is evidence that suggests that Viagra may work to amplify the "pump" response during training. The pump is thought to happen when contracting muscle fibers signal local vascular relaxation (increasing the blood flow to the working muscles). According to KS Lau and coworkers, NO generated by neuronal NO synthase in contracting skeletal muscle fibers may regulate vascular relaxation via a cGMP-mediated pathway. Since the mechanism of action for Viagra is amplification of the cGMP pathway, there is ample reason to believe that the drug may indeed affect the blood flow and pump to the muscle, and therefore indirectly aid in the hypertrophy response.
Friday, October 5, 2007
Andropen 275
Anabolic Steroids Profile
Andropen 275
Andropen ( Andropen 275 ) is a five-ester blend of testosterone produced by British Dragon, and is clearly an attempt to profit off of the popularity of Sustanon. Actually, if you are inclined to use blended products such as this (and personally, I´m not anymore), then I think you´ll find this to be a product far superior to Sustanon.
Andropen contains 20mgs of Testosterone Acetate, 75mgs of Testosterone Cypionate, 90mgs of Testosterone Decanoate, and 40mgs each of Testosterone Propionate and Phenylpropionate in a 20ml bottle. I am very impressed with the fact that this product appears to be designed specifically for bodybuilders and athletes, and certainly if I wanted to create a long, medium, and short estered testosterone product, it would be something like this one. Also, due to that fact, I think I´d recommend shooting it EOD, or E3D or so& .giving you a very decent and relatively stable level of hormone in your body. A few years back, I made a testosterone blend for my own use out of powders, which was essentially a five estered testosterone (the same esters as Sust + 100mgs of test with the Cypionate ester per milliliter). Anyway, now it seems that every Underground Lab is involved with this type of thing. It´s not uncommon to see a price list with several "custom blends" or "house blends" of various estered testosterone´s (or sometimes Trenbolones, or whatever).
Testosterone is a relatively cheap drug (the cheapest, actually, in terms of anabolics), and that´s why it´s not actually a bad choice for blended products. In terms of "bang for the buck", it´s a great choice, as it can do just about everything. It induces changes in both the shape as well as size as muscle fibers (1). It can change the appearance and the number of muscle fibers (1), also, which is definitely a good thing for the cosmetic athlete (read: bodybuilder). Testosterone has the profound ability to protect your muscle from catabolic (muscle wasting) glucocorticoid hormones (2), although not as well as (for example) Tren or other such (more expensive) drugs. Glucocorticoid hormones send a message to muscle cells to release stored protein, while Testosterone sends a message to muscle cells to store more contractile protein (called actin and myosin). In this way, these two hormones are at war with each other to cause anabolic vs. catabolic effects. Usually they are at a stalemate (which is why you don´t gain weight constantly, nor lose it). When you add in some Testosterone (such as Andropen 275), you shift the scales in favor of anabolism, and away from catabolism. In addition to this, Testosterone has the ability to increase erythropoiesis (red blood cell production) in your kidneys (3), and a higher Red Blood Cell (RBC) count is highly sought after by many athletes because it may improve endurance via better oxygenated blood. More RBCs can also improve recovery from strenuous physical activity, and seems to give the muscles a more "full" look when bodyfat levels are reasonably low. Agression levels often rise dramatically with the use of exogenous testosterone (9), and due to some of the short esters in Andropen 275, I´d expect this effect to become realized within the first day of injection.
All of these great benefits are to be had with the use of test enth alone, but realistically, it will be part of a cycle containing one or more other drugs. People who are bulking will probably choose Deca or Eq (possibly with Dbol as well) and those who are cutting will probably steer towards Eq and perhaps Trenbolone. Very often users will shoot this drug once or twice a week, but blood levels are still above baseline with this drug at around day eight (10).Common wisdom holds that the testosterone portion of any such cycle should be equal to or greater than any other injectable drug(s) portion (on a mg basis)& I believe that you can get away with less, but in general, this is a good guideline.
The real advantage to this product, in my opinion, over Sustanon is in its practicality. As you know, I´m not a huge fan of multi-estered products, because it seems that this gives the manufacturer carte blanche to charge whatever they want. Well, this product costs roughly $150, for a 20ml, multi use vial. When compared to buying Sustanon by the amp, you could be paying up to $50 more for the same amount of testosterone. If you are looking for a product of this nature, this is one that I would actually recommend.
This product should provide less of the watery "bloated look" that an equal amount of (for example) testosterone cypionate would give, but more than you´d get with testosterone propionate. This makes it a possible choice for use in either a bulking or cutting cycle, or the ever popular "lean mass" cycle we´re seeing lately, on Steroid.com. Of course, the usual side effects experienced with any testosterone use would be expected with this product: Acne, water-retention, gyno, etc& And so would all of the positive effects we use testosterone for: muscle Gain, fat loss, strength gain, etc&
Really, as I´ve said numerous times, the one principal drawback to using blends of testosterone tends to be their high cost as compared with single ester tests. If this product could be had cheaply, I wouldn´t hesitate to recommend it.
Testosterone + 5 esters [4-androstene-3-one, 17beta-ol] Molecular Weight of base: 288.429 Molecular Weight of Acetate ester: 60.0524 Molecular Weight of Propionate ester: 74.0792 Molecular Weight of Phenylpropionate ester: 150.174 Molecular Weight of Cypionate ester: 132.1184 Molecular Weight of Decanoate ester: 172.2668 Formula (base): C19 H28 O2 Formula of Acetate ester: C2 H4 O2 Formula of Propionate ester: C3H6O2 Formula of Phenylpropionate ester:C9 H10 O2 Formula of Cypionate ester: C8 H14 O2 Formula of Decanoate ester: C10 H20 O2 Manufacturer: British Dragon Effective dose (injectable): (Men) 550mgs-1,100mgs+/week Active Life: 14 days Detection Time: 3 months (projected) Anabolic/Androgenic Ratio (Range):100:100 References:
Anat Histol Embryol. 2003 Apr;32(2):70-9. J Lab Clin Med. 1995 Mar;125(3):326-33. Zhonghua Nan Ke Xue. 2003;9(4):248-51 J Clin Endocrinol Metab. 2003 Apr;88(4):1478-85 J Clin Endocrinol Metab. 2004 Feb;89(2):718-26. Am J Physiol. 1998 Jun;274(6 Pt 1):C1645-52. Biochim Biophys Acta. 1995 May 11;1244(1):117-20. Am J Physiol Endocrinol Metab. 2001 Dec;281(6):E1172-81. Health Psychol. 1990;9(6):774-91. Fertility and Sterility 33.
Andropen 275
Andropen ( Andropen 275 ) is a five-ester blend of testosterone produced by British Dragon, and is clearly an attempt to profit off of the popularity of Sustanon. Actually, if you are inclined to use blended products such as this (and personally, I´m not anymore), then I think you´ll find this to be a product far superior to Sustanon.
Andropen contains 20mgs of Testosterone Acetate, 75mgs of Testosterone Cypionate, 90mgs of Testosterone Decanoate, and 40mgs each of Testosterone Propionate and Phenylpropionate in a 20ml bottle. I am very impressed with the fact that this product appears to be designed specifically for bodybuilders and athletes, and certainly if I wanted to create a long, medium, and short estered testosterone product, it would be something like this one. Also, due to that fact, I think I´d recommend shooting it EOD, or E3D or so& .giving you a very decent and relatively stable level of hormone in your body. A few years back, I made a testosterone blend for my own use out of powders, which was essentially a five estered testosterone (the same esters as Sust + 100mgs of test with the Cypionate ester per milliliter). Anyway, now it seems that every Underground Lab is involved with this type of thing. It´s not uncommon to see a price list with several "custom blends" or "house blends" of various estered testosterone´s (or sometimes Trenbolones, or whatever).
Testosterone is a relatively cheap drug (the cheapest, actually, in terms of anabolics), and that´s why it´s not actually a bad choice for blended products. In terms of "bang for the buck", it´s a great choice, as it can do just about everything. It induces changes in both the shape as well as size as muscle fibers (1). It can change the appearance and the number of muscle fibers (1), also, which is definitely a good thing for the cosmetic athlete (read: bodybuilder). Testosterone has the profound ability to protect your muscle from catabolic (muscle wasting) glucocorticoid hormones (2), although not as well as (for example) Tren or other such (more expensive) drugs. Glucocorticoid hormones send a message to muscle cells to release stored protein, while Testosterone sends a message to muscle cells to store more contractile protein (called actin and myosin). In this way, these two hormones are at war with each other to cause anabolic vs. catabolic effects. Usually they are at a stalemate (which is why you don´t gain weight constantly, nor lose it). When you add in some Testosterone (such as Andropen 275), you shift the scales in favor of anabolism, and away from catabolism. In addition to this, Testosterone has the ability to increase erythropoiesis (red blood cell production) in your kidneys (3), and a higher Red Blood Cell (RBC) count is highly sought after by many athletes because it may improve endurance via better oxygenated blood. More RBCs can also improve recovery from strenuous physical activity, and seems to give the muscles a more "full" look when bodyfat levels are reasonably low. Agression levels often rise dramatically with the use of exogenous testosterone (9), and due to some of the short esters in Andropen 275, I´d expect this effect to become realized within the first day of injection.
All of these great benefits are to be had with the use of test enth alone, but realistically, it will be part of a cycle containing one or more other drugs. People who are bulking will probably choose Deca or Eq (possibly with Dbol as well) and those who are cutting will probably steer towards Eq and perhaps Trenbolone. Very often users will shoot this drug once or twice a week, but blood levels are still above baseline with this drug at around day eight (10).Common wisdom holds that the testosterone portion of any such cycle should be equal to or greater than any other injectable drug(s) portion (on a mg basis)& I believe that you can get away with less, but in general, this is a good guideline.
The real advantage to this product, in my opinion, over Sustanon is in its practicality. As you know, I´m not a huge fan of multi-estered products, because it seems that this gives the manufacturer carte blanche to charge whatever they want. Well, this product costs roughly $150, for a 20ml, multi use vial. When compared to buying Sustanon by the amp, you could be paying up to $50 more for the same amount of testosterone. If you are looking for a product of this nature, this is one that I would actually recommend.
This product should provide less of the watery "bloated look" that an equal amount of (for example) testosterone cypionate would give, but more than you´d get with testosterone propionate. This makes it a possible choice for use in either a bulking or cutting cycle, or the ever popular "lean mass" cycle we´re seeing lately, on Steroid.com. Of course, the usual side effects experienced with any testosterone use would be expected with this product: Acne, water-retention, gyno, etc& And so would all of the positive effects we use testosterone for: muscle Gain, fat loss, strength gain, etc&
Really, as I´ve said numerous times, the one principal drawback to using blends of testosterone tends to be their high cost as compared with single ester tests. If this product could be had cheaply, I wouldn´t hesitate to recommend it.
Testosterone + 5 esters [4-androstene-3-one, 17beta-ol] Molecular Weight of base: 288.429 Molecular Weight of Acetate ester: 60.0524 Molecular Weight of Propionate ester: 74.0792 Molecular Weight of Phenylpropionate ester: 150.174 Molecular Weight of Cypionate ester: 132.1184 Molecular Weight of Decanoate ester: 172.2668 Formula (base): C19 H28 O2 Formula of Acetate ester: C2 H4 O2 Formula of Propionate ester: C3H6O2 Formula of Phenylpropionate ester:C9 H10 O2 Formula of Cypionate ester: C8 H14 O2 Formula of Decanoate ester: C10 H20 O2 Manufacturer: British Dragon Effective dose (injectable): (Men) 550mgs-1,100mgs+/week Active Life: 14 days Detection Time: 3 months (projected) Anabolic/Androgenic Ratio (Range):100:100 References:
Anat Histol Embryol. 2003 Apr;32(2):70-9. J Lab Clin Med. 1995 Mar;125(3):326-33. Zhonghua Nan Ke Xue. 2003;9(4):248-51 J Clin Endocrinol Metab. 2003 Apr;88(4):1478-85 J Clin Endocrinol Metab. 2004 Feb;89(2):718-26. Am J Physiol. 1998 Jun;274(6 Pt 1):C1645-52. Biochim Biophys Acta. 1995 May 11;1244(1):117-20. Am J Physiol Endocrinol Metab. 2001 Dec;281(6):E1172-81. Health Psychol. 1990;9(6):774-91. Fertility and Sterility 33.
Thursday, October 4, 2007
Ketotifen
Ketotifen
Ketotifen was made popular by its ability to inhibit the down regulation of beta receptors caused by drugs like clenbuterol. Clenbuterol, albuterol, and Ephedrine used to be cycled on and off because they desensitize the various receptors they act on to produce their lipolytic effect. Ketotifen would therefore allow the use of these fat burning drugs for much longer periods.
If you´ve read my writings on Clenbuterol, you already know that Benadryl (the anti-histimine) can also be used for this same purpose, and is 10x cheaper and infinitely more available to most people. So why am I bothering to write about Ketotifen at all?
Ketotifen, in medical circles, is also recognized for its ability to lower levels of the cytokine Tumor Necrosis Factor-alpha (TNF-alpha), which is a catabolic hormone, and this is a property that Benadryl does not have to my knowledge. TNF-alpha lowers both testosterone and IGF-1 levels (3) (4), and strenuous exercise elevates TNF-alpha levels (5). TNF-alpha has also been shown to increase insulin resistance,, which we certainly don´t want.
Ketotifen and Weigh Loss Ketotifen is used by people suffering from wasting diseases partially caused by TNF-alpha. I think, however, its ability to lower TNF-alpha is going to be overshadowed by anabolic effects produced by anabolic steroids. In one study involving AIDS patients, combining Ketotifen and Oxymetholone (Anadrol 50) showed that the Ketotifen didn´t add much to the Oxymetholone induced weight gain (1). Hence, you are reading this profile in the "Ancilliaries" portion of this book, and not the "Fat - Burning" part, even though Ketotifen is typically used as part of a fat burning cycle including clen. Benadryl is simply too much cheaper and readily available to use Ketotifen in its place with Clen. However, for Post-Cycle-Therapy, Ketotifen and it´s ability to lower TNF-alpha, is a very valuable tool. You see, Hypogonadism (low testosterone) often accompanies elevated TNF-alpha levels (6), and after a cycle of anabolic steroids, you are going to be in a hypogonadal state, with elevated TNF-alpha. Thus, taking Ketotifen with your PCT is probably a very good idea. I recommend 1-3mgs/day before bed because this stuff will make you pretty drowsy.
References:
Oxymetholone promotes weight gain in patients with advanced human immunodeficiency virus (HIV-1) infection. Br J Nutr. 1996 Jan;75(1):129-38. Smart T. GMHC Treat Issues. 1995 May;9(5):7-8, 12. Mauduit C, et.al Endocrinology 1998 Jun;139(6):2863-. Lang CH et.al Growth Horm IGF Res 2001 Aug;11(4):250-60. Pedersen BK et. al. Exerc Immunol Rev 2001;7:18-31. Malkin CJ et.al. J Clin Endocrinol Metab. 2004 Jul;89(7):3313-8.
Ketotifen was made popular by its ability to inhibit the down regulation of beta receptors caused by drugs like clenbuterol. Clenbuterol, albuterol, and Ephedrine used to be cycled on and off because they desensitize the various receptors they act on to produce their lipolytic effect. Ketotifen would therefore allow the use of these fat burning drugs for much longer periods.
If you´ve read my writings on Clenbuterol, you already know that Benadryl (the anti-histimine) can also be used for this same purpose, and is 10x cheaper and infinitely more available to most people. So why am I bothering to write about Ketotifen at all?
Ketotifen, in medical circles, is also recognized for its ability to lower levels of the cytokine Tumor Necrosis Factor-alpha (TNF-alpha), which is a catabolic hormone, and this is a property that Benadryl does not have to my knowledge. TNF-alpha lowers both testosterone and IGF-1 levels (3) (4), and strenuous exercise elevates TNF-alpha levels (5). TNF-alpha has also been shown to increase insulin resistance,, which we certainly don´t want.
Ketotifen and Weigh Loss Ketotifen is used by people suffering from wasting diseases partially caused by TNF-alpha. I think, however, its ability to lower TNF-alpha is going to be overshadowed by anabolic effects produced by anabolic steroids. In one study involving AIDS patients, combining Ketotifen and Oxymetholone (Anadrol 50) showed that the Ketotifen didn´t add much to the Oxymetholone induced weight gain (1). Hence, you are reading this profile in the "Ancilliaries" portion of this book, and not the "Fat - Burning" part, even though Ketotifen is typically used as part of a fat burning cycle including clen. Benadryl is simply too much cheaper and readily available to use Ketotifen in its place with Clen. However, for Post-Cycle-Therapy, Ketotifen and it´s ability to lower TNF-alpha, is a very valuable tool. You see, Hypogonadism (low testosterone) often accompanies elevated TNF-alpha levels (6), and after a cycle of anabolic steroids, you are going to be in a hypogonadal state, with elevated TNF-alpha. Thus, taking Ketotifen with your PCT is probably a very good idea. I recommend 1-3mgs/day before bed because this stuff will make you pretty drowsy.
References:
Oxymetholone promotes weight gain in patients with advanced human immunodeficiency virus (HIV-1) infection. Br J Nutr. 1996 Jan;75(1):129-38. Smart T. GMHC Treat Issues. 1995 May;9(5):7-8, 12. Mauduit C, et.al Endocrinology 1998 Jun;139(6):2863-. Lang CH et.al Growth Horm IGF Res 2001 Aug;11(4):250-60. Pedersen BK et. al. Exerc Immunol Rev 2001;7:18-31. Malkin CJ et.al. J Clin Endocrinol Metab. 2004 Jul;89(7):3313-8.
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